痴呆症多病症:当前的前景和未来的挑战
Lucy E Stirland1,2, Radmila Choate3,4, Preeti Pushpalata Zanwar5
1Division of Psychiatry, Institute of Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.
概括
多病症,即多种慢性疾病的存在,影响了超过86%的痴呆患者,恶化了他们的健康状况. 通过生命历程研究来理解这种复杂的关系,对于预防和治疗痴呆症至关重要.
科学领域:
- 老年学是指老年学的学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 多病症,定义为两个或两个以上的慢性健康状况的同时发生,在痴呆症患者中非常普遍,影响了该人口的86%以上.
- 多病症的存在与加速的认知和功能衰退,生活质量下降,医疗保健利用率增加以及痴呆症患者的死亡率增加有关.
研究的目的:
- 强调研究复杂的,可能是多病症和痴呆症之间的双向关系的关键需要.
- 突出多重疾病在痴呆症护理,治疗决策和临床试验参与中所带来的挑战.
- 倡导长期前性研究,调查特定疾病组合,环境和遗传因素对整个生命周期的认知健康的影响.
主要方法:
- 该研究强调了长期前性研究设计的必要性.
- 它呼吁调查特定疾病组合及其与环境和遗传因素的相互作用.
- 专注于分析整个生命过程中的影响,以了解痴呆症的发展和进展.
主要成果:
- 多种疾病明显加剧了痴呆症患者的负面结果.
- 慢性疾病和痴呆症之间的相互作用是双向的,高血压和糖尿病等疾病增加了痴呆症的风险.
- 慢性疾病的管理因认知障碍而复杂化,多病症患者经常被排除在临床试验之外.
结论:
- 对多发性疾病的前性,终身研究对于制定有效的痴呆风险降低策略至关重要.
- 了解多病症和痴呆症之间的多方面的关系将为创建改进的预测模型提供信息.
- 这项研究对于设计包容性干预措施至关重要,这些干预措施可以满足全球多样化人口在整个生活中的需求.
相关概念视频
01:30Dementia
165
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
165
01:26Alzheimer's Disease: Overview
669
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
669
01:22Alzheimer's Disease: Treatment
262
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
262
01:27Diagnostic and Statistical Manual of Mental Disorders (DSM)
151
The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
151
01:15Methods of Documentation VI: Case Management Model
628
The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
For example, a patient with a chronic...
628
01:21Dimensions of Health and Illness
8.2K
The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
8.2K