母亲喘与子女先天性心脏缺陷的关联
Mari Kemppainen1,2, Turkka Kirjavainen3, Emmi Helle4,5
1Vantaa and Kerava Wellbeing County, Martinlaakso Health Station, Vantaa, Finland.
Acta obstetricia et gynecologica Scandinavica
|August 4, 2025
概括
孕产妇的喘和过敏状况适度增加后代患先天性心脏缺陷 (CHD) 的风险,特别是腹腔隔膜缺陷 (VSD). 这些发现突出了过敏性炎症对胎儿心脏发育的潜在原性影响.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 喘是孕妇中普遍存在的慢性疾病.
- 母亲喘与先天性形风险增加有关,特别是先天性心脏缺陷 (CHD).
- 心室隔膜缺陷 (VSD) 是最常见的心血管疾病类型.
研究的目的:
- 调查母亲喘与后代心血管疾病风险之间的关联.
- 为了检查母亲的性倾向和喘药物使用对心脏病风险的影响.
主要方法:
- 使用芬兰出生队列 (1996-2018) 进行的回顾性,基于人口的研究.
- 四个国家卫生登记册的数据链接.
- 包括超过127万个母婴对.
主要成果:
- 孕产妇喘与整体心脏病 (OR 1.18) 和静脉喘 (OR 1.19) 的相关性较弱.
- 过敏性 (OR 1.33) 和非过敏性喘 (OR 1.27) 都与心脏病风险增加有关.
- 母亲的过敏状况 (例如,亚托皮性皮肤炎,过敏性鼻炎) 也与更高的心脏病和静脉疾病风险有关.
结论:
- 母亲的喘和过敏倾向与后代心血管疾病风险的适度增加有关,特别是VSD.
- 非过敏性喘与心血管疾病有关,尤其是右侧缺陷.
- 孕产妇的过敏性炎症可能对胎儿心脏发育产生原性影响.
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