一例ICI相关的关节炎,由托里帕利马布引起,最初呈现为两个下肢的胀
Jie-Ling Zhang1, Hao Yang2, Zhi-Li Zhou3
1Department of Radiation Oncology, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Affiliated Central Hospital of Huzhou University, Huzhou, Zhejiang, China.
Journal of chemotherapy (Florence, Italy)
|August 4, 2025
概括
免疫检查点抑制剂 (ICI) 可能导致关节炎 (IA),这是需要谨慎管理的副作用. 本案例报告强调了结肠癌患者IA的成功类固醇治疗,证明了有效的症状控制以及瘤管理.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 免疫检查点抑制剂 (ICI) 提供了新的癌症疗法,但可以诱导与免疫相关的不良事件.
- 免疫检查点抑制剂相关关节炎 (IA) 是一个新兴问题,通常呈现无特异性,没有明确的诊断标准.
- 用ICI治疗晚期结肠癌需要意识到潜在的毒性,如IA.
研究的目的:
- 在接受托里帕利马布治疗的晚期结肠癌患者中报告IA病例.
- 为了说明IA的临床表现和管理.
- 在癌症免疫治疗的背景下,为了解IA及其治疗做出贡献.
主要方法:
- 一份病例报告详细介绍了一个患有晚期结肠癌的患者.
- 在托里帕利马布 (Toripalimab) 给药后观察IA发展.
- 对皮质类固醇治疗反应的评估.
主要成果:
- 该患者在接受Toripalimab治疗晚期结肠癌后发展了IA.
- 随着类固醇的使用,IA症状显著改善.
- 患者的结肠癌在治疗期间保持良好控制.
结论:
- 艾亚是一种与Toripalimab.b.等ICI相关的潜在不良事件.
- 皮质类固醇可以作为IA的有效治疗方法,在不影响瘤控制的情况下控制症状.
- 这一案例强调了在接受癌症免疫治疗的患者中识别和管理IA的重要性.
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