通过有机电化学晶体管进行神经形态调制炎症信号的aptamer介导人工突触
Yuqing Ding1, You Kuai2,3, Rongpei Li1
1Department of Materials Science, Fudan University, Shanghai, 200433, P. R. China.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|August 4, 2025
概括
这项研究引入了一种基于aptamer的人工突触晶体管,可以检测关键的炎症蛋白质 - - 互白素-6 (IL-6). 该设备将IL-6信号转化为电输出,用于监测生物系统中的炎症应激.
科学领域:
- 生物医学工程 生物医学工程
- 神经科学是一个神经科学.
- 材料科学 材料科学 材料科学
背景情况:
- 神经形态计算显示出生物电子接口的前景.
- 当前的人工突触装置难以处理生物蛋白信号.
- 介质素-6 (IL-6) 是炎症性压力的关键生物标志物.
研究的目的:
- 开发一种以阿普他默为媒介的人工突触晶体管,用于检测IL-6.
- 为了使蛋白质信号转化为神经形态电输出.
- 创建一个混合的神经传感系统来监测炎症状况.
主要方法:
- 使用分子对接来识别IL-6的aptamer选择.
- 制造一个含水的人工突触晶体管.
- 在生物电解质和败血症小鼠模型中进行体外和体内试验.
- 机器学习用于信号分析和状态歧视.
主要成果:
- 该设备在生物电解质中选择性地检测IL-6,从下午0.5点到50nm的线性响应.
- 结合IL-6转化为时间和度依赖的电信号,具有突触可塑性.
- 在小鼠体内植入表明稳定的IL-6监测和可靠的突触反应.
- 机器学习准确地区分了正常和病态状态.
结论:
- 通过aptamer介导的突触晶体管成功地将生物化学信号与神经形态编码结合起来.
- 这项技术为混合神经传感系统和生物电子接口提供了一个新的平台.
- 该设备显示了对炎症性压力和疾病状态的实时监测的潜力.
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