对重症患者实施皮佩拉西林-塔扎巴克坦连续输液:单中心回顾图表审查
Kylie Landry1, Meghan MacKenzie2, Sarah Burgess3
1, BScPharm, ACPR, is a Clinical Pharmacist - Internal Medicine and Critical Care with the Pharmacy Department, Nova Scotia Health, Central Zone, Halifax, Nova Scotia.
在重症监护病房 (ICU) 成功实施了持续输注piperacillin-tazobactam (P/T),改善了重症患者的抗生素输送. 这项质量改进倡议证明了成功采用协议,没有发现安全事故.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 危急病患者的药理动力学变化可能导致微生物药物度低于最佳水平.
- 增加非发酵性阴性菌 (NFGNB) 的抗菌耐药性需要优化抗生素剂量.
- 指导方针建议长时间输注β-乳酸抗生素以改善药理动力学/药理动力学.
研究的目的:
- 评估在重症监护病房 (ICU) 实施连续输液皮佩拉西林-塔扎巴克坦 (P/T) 方案.
- 评估二次结果,包括ICU死亡率,停留时间 (LOS) 和安全事件.
- 确定NFGNB的流行率及其P/T的最小抑制度 (MIC).
主要方法:
- 在2020年10月至2022年10月期间,在ICU接受P / T的200名患者的单中心回顾性研究.
- 从数字记录和重症监护数据库中收集的数据.
- 成功实施的定义是满足8个预定义标准中的至少6个.
主要成果:
- 连续输液P/T方案在78.0% (156/200) 的患者中成功实施.
- 在ICU的死亡率为20.5% (41/200),中位数LOS为4.9天.
- 没有发现与该协议相关的安全事件;NFGNB的流行率为3.1%.
结论:
- 在大多数ICU患者中,成功实施了连续输液P/T.
- 需要改进的领域包括完善订单集,跨专业教育和协作.
- 连续输注P/T是优化危急病患者抗生素治疗的可行策略.
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