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伦丁南通过优化T细胞分化来增强固体瘤中CAR-T细胞的功效

Xiangyun Niu1,2, Pengchao Zhang1,2, Zhongming Liu1

  • 1Guangdong Immune Cell Therapy Engineering and Technology Research Center, Center for Protein and Cell-based Drugs, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.

Frontiers in immunology
|August 4, 2025
PubMed
概括

伦丁南 (LTN) 通过增强免疫细胞功能和持久性来增强固体瘤的CAR-T细胞疗法. 这种新的策略改善了瘤控制,并可能克服癌症治疗当前的局限性.

关键词:
在CAR-T细胞疗法中.中央记忆中的T细胞.长时间的延续.固体瘤是一个固体瘤.瘤微环境是一个微环境.

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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