埃多克萨班诱导肠球炎:第一个病例报告显示出明显的内镜和组织学特征
Katsuya Endo1, Jun Yamada1, Tomofumi Katayama1
1Department of Gastroenterology Tohoku Medical and Pharmaceutical University Miyagi Japan.
DEN open
|August 4, 2025
概括
直接口服抗凝剂 (DOAC) 可能导致肠球炎. 本病例报告详细介绍了埃多克萨班诱导的肠炎,其特征是血性腹和独特的内镜检查结果,在药物停止后消失.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 直接口服抗凝剂 (DOAC) 通常用于预防心房和静脉血栓栓塞的中风.
- 胃肠道出血和腹是已知的DOACs的副作用.
- 由于DOAC诱导的肠球炎尚未被认为是一个独特的临床实体.
研究的目的:
- 报告第一个EDOXABAN诱导的肠球炎病例.
- 要突出这种情况的临床,内镜和组织病理特征.
- 强调需要提高临床意识和进一步研究的需要.
主要方法:
- 一个案例报告,一名75岁的妇女在开始服用edoxaban后出现了血淋淋的腹.
- 诊断程序包括胆管结肠镜和组织病理学检查.
- 在停止服用埃多克萨班后临床疗程评估.
主要成果:
- 患者在开始服用edoxaban5天后出现了血性腹和厌食症.
- 胆管结肠镜检查显示了胆管和结肠,并有下粘膜下出血.
- 组织病理学显示状缩,淋巴扩张和粘膜炎症,与其他原因不一致.
- 症状在停止edoxaban后的三天内消失,三个月后粘膜完全愈合.
结论:
- 这些发现表明,埃多克萨班诱导的肠炎是DOACs潜在的不良影响.
- 这一案例强调了在服用DOAC的患者中考虑药物诱导肠道炎的重要性,这些患者呈现出无法解释的胃肠道症状.
- 需要进一步的研究来确定DOAC诱导的肠炎作为一个独立的临床实体.
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