一项随机对照试验比较水友涂层与未涂层聚氨双J支架:它是否会影响支架相关症状?
Gaurav Sharma1, Naveen Kumar1, Diptiranjan Bai1
1Department of Urology, Pushpanjali Hospital and Research Centre, Agra, Uttar Pradesh, India.
概括
与无涂层支架相比,水友涂层双J支架显著降低了尿路症状和疼痛. 这改善了患者的生活质量,这表明水友涂层对尿路支架的结果有益.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物材料科学 生物材料科学
- 医疗器械 医疗器械
背景情况:
- 尿道支架在内泌尿外科手术后至关重要,但可能导致严重的发病率.
- 下尿路症状 (LUTS),疼痛和生活质量降低 (QoL) 是与尿路支架相关的常见并发症.
- 支架材料和涂料的进步旨在减轻这些不良影响.
研究的目的:
- 为了在接受聚氨双J (DJ) 支架的患者中前性地比较尿路症状和QoL,包括带有或没有含水性聚烯皮罗立涂层的患者.
- 为了评估水友涂层对疼痛和特定尿路症状的影响.
主要方法:
- 一项前性随机研究,涉及60名接受DJ支架安置的成年患者.
- 患者被随机分配在2:1的比例中接受水性涂层 (n=20) 或无涂层 (n=40) 聚氨DJ支架 (5F直径,长26厘米).
- 尿路症状,疼痛和QOL使用尿路支架症状问卷 (USSQ) 在安置后3-4周评估.
主要成果:
- 带有水性涂层支架的患者报告尿症状得分显著降低 (10.75比15.28,P<0.001) 和疼痛得分 (1.50比3.18,P<0.001).
- 在爱水组中,生活质量得分明显更好 (3.0对5.23,P<0.001).
- 频率,夜,急性和灼热的排尿等特定症状显著减少; 60%的水友群体患者报告没有疼痛,而非水友群体的7.5% (P < 0.001).
结论:
- 水友性涂层的DJ支架显著缓解了LUTS并改善了患者的QoL.
- 这些发现表明,水友涂层可以提高尿路支架相关的结果.
- 需要进一步的大规模研究来验证这些有希望的结果.
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