从上到下生成的微型和纳米塑料降低了巨细胞的生存能力,而不会引起促炎反应
Annemijne E T van den Berg1, Kas J Adriaans1, Luke A Parker2
1Institute for Risk Assessment Sciences, Utrecht University, Yalelaan 104-106, 3584 CM Utrecht, The Netherlands.
Microplastics and nanoplastics
|August 4, 2025
概括
碎片化微型和纳米塑料 (MNP) 在人类巨细胞中表现出细胞毒性,但没有直接引发炎症. 较高的MNP度导致细胞损伤,可能间接影响免疫功能.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
背景情况:
- 微和纳米塑料颗粒 (MNP) 是无处不在的环境污染物.
- 人类通过各种途径不可避免地接触到MNP.
- 碎片化MNP对巨细胞的免疫毒性影响尚不清楚.
研究的目的:
- 研究碎片化MNP对人类巨细胞的细胞毒性和促炎作用.
- 评估不同MNP类型,大小和度对巨细胞反应的影响.
主要方法:
- 人类THP-1巨细胞暴露于碎片的PVC,PP,PA6.6和初级PS粒子,以及TiO2.2.
- 用流式细胞计和共聚焦显微镜分析了粒子吸收.
- 通过溶解体和线粒体活性,LDH泄漏,NF-κB活性和细胞因子分泌来测量巨细胞的反应.
主要成果:
- 巨细胞以以度,时间和大小为依赖的方式吸收PS粒子.
- MNPs增加了溶酶体活性,表明潜在的积累.
- 碎片化的MNP诱导了细胞毒性 (线粒体活性降低,LDH泄漏增加),但没有显著的促炎细胞因子释放 (IL-6,IL-1β,TNF-α).
结论:
- 碎片化的MNP在较高度下对人类巨细胞具有细胞毒性潜力.
- 没有观察到巨细胞对碎片化MNP的直接促炎反应.
- 物理化学变化的MNP可能间接影响免疫系统的功能,需要进一步研究.
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