评估维生素D和甲型胺在糖尿病病中的预防和脏保护作用
Lavanya B Ramegowda1, Prashant Vishwanath1,2, Paramahans V Salimath1
1Center of Excellence in Molecular Biology and Regenerative Medicine, Department of Biochemistry, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
Oxidative medicine and cellular longevity
|August 4, 2025
概括
维生素D与甲胺结合,有效地减缓了大鼠糖尿病病 (DN) 的进展. 这种组合改善了新陈代谢控制,减少了氧化应激,并保持了功能,显示了DN管理的希望.
科学领域:
- 脏病学和内分泌学
- 药理学和治疗学 药理学和治疗学
背景情况:
- 糖尿病病 (DN) 是糖尿病 (DM) 的严重并发症,导致全球末期病 (ESRD).
- DN病原包括氧化应激 (OS),慢性炎症和纤维化,目前的治疗方法在阻止疾病进展方面存在局限性.
研究的目的:
- 评估维生素D单独或与甲福明结合的治疗效果,在小鼠模型中评估链毒素诱导的糖尿病病 (STZ-DN).
- 评估这些治疗对代谢参数,功能,氧化应激标志物和关键分子通路的影响.
主要方法:
- 雄性Wistar大鼠使用链毒素 (STZ) 诱导糖尿病,并用不同剂量的维生素D,甲胺或它们的组合治疗12或21周.
- 评估了空腹血糖 (FBG),脂质样本,功能标志物和OS指标.
- 利用组织病理学分析和免疫组织化学 (IHC) 来评估脏结构变化和蛋白质表达 (TGF-β,VEGF,Nrf2,VDR).
主要成果:
- 维生素D和美特福明的联合治疗在21周时表现出FBG (-49.8%) 最显著的减少.
- 观察到甘油三和OS标记物 (H2O2,NO) 的显著降低,以及增强的抗氧化酶活性 (GR,SOD,GPx).
- 组织学和IHC显示,治疗组中脏结构保存,纤维化减少,VDR和Nrf2表达增加,VEGF和TGF-β水平降低.
结论:
- 维生素D,特别是与甲福明结合时,有效地减轻了大鼠糖尿病病的进展.
- 组合疗法增强了新陈代谢控制,减轻了氧化应激和炎症,并保持了的结构和功能.
- 研究结果支持维生素D作为DN的潜在辅助疗法,需要进一步的临床研究.
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