血液中重金属含量与COPD风险之间的关联:基于NHANES数据的横截面研究
Xingshi Hua1,2, Lingyun Zhu1,3, He Chen2
1Liaoning University of Traditional Chinese Medicine, Shenyang, China.
血中和含量升高与患慢性阻塞性肺病 (COPD) 的风险更高有关. 这项研究还发现了,和COPD风险之间的非线性关联.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 肺部医学 肺部医学
背景情况:
- 像 (Cd), (Pb), (Hg), (Se) 和 (Mn) 这样的重金属是环境污染物.
- 接触这些金属可能会通过氧化应激和炎症增加慢性阻塞性肺病 (COPD) 的风险.
- 目前关于重金属暴露与COPD之间联系的证据有限且不确.
研究的目的:
- 研究血液中Cd,Pb,Hg,Se和Mn的含量与患上COPD的风险之间的联系.
- 探索这些重金属对COPD的潜在非线性关系和预测值.
主要方法:
- 从国家健康和营养检查调查 (NHANES) 中对7,458名个人进行横截面分析.
- 根据医生的自我报告诊断确定COPD状态.
- 采用多变量逻辑回归,平滑曲线和接收器操作特征 (ROC) 曲线分析.
主要成果:
- 与对照组相比,COPD患者的血液中Cd和Pb水平显著更高.
- 血中Cd和Pb水平升高与COPD风险增加独立相关 (分别为OR=1.27和OR=1.69).
- 在Cd和Mn水平和COPD风险之间观察到非线性正相关性;Pb显示了最高的预测值 (AUC=0.6744).
结论:
- 血液中Cd和Pb水平与COPD的可能性之间存在显著的关联.
- 建议Cd,Mn暴露和COPD之间存在非线性正相关性.
- 重金属在预测COPD风险方面表现出不同的敏感性和特异性.
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