疼痛障碍的核心结果集:研究和报告质量的系统审查
Ying Cui1,2,3, Bo Li1,2,3, Shiyi Jiang4
1Department of Acupuncture, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Journal of pain research
|August 4, 2025
概括
这次审查评估了疼痛的核心成果集. 大多数缺乏方法严格性,突出了在制定结果清单时需要更好的患者和专业人员投入的需要.
科学领域:
- 疼痛研究 疼痛研究
- 临床试验方法论 临床试验方法论
- 健康研究成果研究结果
背景情况:
- 核心结果集 (COS) 对于针对疼痛相关疾病的临床试验标准化结果至关重要.
- 评估现有COS的当前研究状态和方法质量对于改善其开发和应用至关重要.
- 疼痛研究需要一致和相关的结果措施,以确保跨研究的可比性和有意义的结果.
研究的目的:
- 系统地审查与疼痛相关疾病的核心结果集 (COS) 的当前研究状况.
- 通过使用核心成果集-发展标准 (COS-STAD) 标准来评估现有COS的方法质量.
- 确定在疼痛研究中开发和应用COS的改进领域.
主要方法:
- 对英语和中文数据库进行了全面的搜索.
- 两位研究人员独立选了研究,并根据预定义的纳入标准提取了数据.
- 使用COS-STAD的11个标准来评估方法质量,包括范围,利益相关方参与和共识过程.
主要成果:
- 分析了22种疼痛障碍的24个COS,主要是在欧洲,亚洲和北美发展的.
- 只有20%的COS完全符合COS-STAD标准,这表明有很大的方法改进空间.
- 干预覆盖范围和初始结果列表的构建得到了最低的分数,这表明需要加强对这些领域的关注.
结论:
- COS的发展应该与有效性试验 (COMET) 中的核心结果措施指南保持一致.
- 建议加强对干预措施的纳入和评估的重视.
- 在初始结果列表设计中整合医疗保健专业人员和患者的观点对于提高COS相关性和适用性至关重要.
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