多发性硬化症中的及其与认知和心理负担的关联
Valeria Pozzilli1,2, Carla Tortorella3, Luca Prosperini3
1Unit of Neurology, Neurophysiology and Neurobiology, Department of Medicine and Surgery, Campus Bio-Medico University, Rome, Italy.
概括
患有多发性硬化症和 (MS+E) 的患者经历了更多的认知障碍,特别是在处理速度和视觉空间记忆方面. 这凸显了对MS+E患者进行专业护理的需要,以改善他们的生活质量.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 临床医学 临床医学
背景情况:
- 在患有多发性硬化症 (pwMS) 的患者中比一般人群更常见2-3倍.
- 与没有 (MS-E) 患者相比,患有多发性硬化和 (MS+E) 的患者表现出较大的皮质损伤.
- 需要特殊管理的MS+E患者的独特认知和神经心理特征仍然不清楚.
研究的目的:
- 研究MS+E患者的认知和神经心理学概况.
- 为了确定MS+E患者是否表现出明显的特征,需要量身定制的管理策略.
- 为了比较MS+E和MS-E患者之间的认知障碍患病率和特定缺陷.
主要方法:
- 分析了来自三个中心的pwMS队列,确定了MS+E患者.
- 一组匹配的MS-E患者被纳入用于比较.
- 进行了认知和神经精神病学测试,将认知障碍 (CI) 定义为在≥1个领域中得分≥1.5 SD低于规范值.
主要成果:
- 认知障碍 (CI) 在MS+E患者 (n=33) 中比MS-E患者 (n=33) 更普遍.
- MS+E患者的处理速度 (p<0.01) 和视觉空间记忆 (p=0.03) 显著降低.
- MS+E与CI (OR 3.6) 独立相关,体化,恐惧症,焦虑和抑郁症是最受影响的神经心理领域.
结论:
- MS+E与增加的认知障碍有关,特别是影响处理速度和视觉空间记忆.
- 在MS+E患者中,心理困扰很普遍,与处理速度有负相关性.
- 针对性,多学科的护理对于MS+E患者来说至关重要,以提高结果和生活质量.
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