西图赫穆处方改善了与代谢功能障碍相关的脂肪性肝病:现实世界队列研究
Liu-Lan Xiang1,2, Yu-Tian Cao1,2, Xiao-Xiao Wang3
1Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, People's Republic of China.
Journal of multidisciplinary healthcare
|August 4, 2025
概括
在一项现实研究中,Xietu Hemu处方 (XHP) 显著改善了代谢功能障碍相关的脂肪性肝病 (MASLD) 标志物. XHP为MASLD提供了一个有前途的治疗选择,显示出显著的疗效与最小的副作用.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 传统中国医药 传统中国医药
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益严重的全球健康挑战.
- 目前对MASLD的治疗选择有限,需要新的治疗策略.
研究的目的:
- 通过使用现实世界的研究方法来评估Xietu Hemu处方 (XHP) 在管理MASLD方面的疗效.
- 评估XHP对MASLD患者肝脏健康和代谢参数的关键指标的影响.
主要方法:
- 一项前性,现实世界的队列研究,涉及262名MASLD患者.
- 通过比较FibroScan参数 (LSM,CAP),身体成分 (BMI,WHR,VFA) 和肝酶来评估治疗的疗效.
- 统计分析包括治疗权重的逆概率 (IPTW) 和日志二项式分析.
主要成果:
- 治疗XHP导致肝硬度测量 (LSM),控制衰减参数 (CAP),BMI,WHR,VFA,脂肪肝指数 (FLI) 和纤维扫描-AST (FAST) 的显著改善.
- 逻辑-二项式分析证实XHP的疗效优于单独的基本治疗 (加权风险比=2.99,p<0.001).
- 亚组分析表明,在各种治疗持续时间和患者特征中,疗效一致;没有报告严重不良事件.
结论:
- 在治疗MASLD时,Xietu Hemu处方 (XHP) 显示出显著的治疗效果.
- 对于MASLD来说,XHP代表了对有限的治疗景观的潜在有价值的补充.
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