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Updated: Sep 13, 2025

Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
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细胞特异性 perfusion 速率驱动 CHO N-1 perfusion 过程中的生长动态和新陈代谢,独立于 perfusion 速率控制方法

Julia Walther1, Tiago Ribeiro da Costa1, Lydia Winkler1

  • 1Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riß, Germany.

Frontiers in bioengineering and biotechnology
|August 4, 2025
PubMed
概括

在N-1 perfusion培养中,优化细胞特异性 perfusion rate (CSPR) 和集成工作体积 (iVVD) 提高了中国子卵巢细胞的生长,以产生单克隆抗体. 这降低了制造成本,提高了效率.

关键词:
在CHO细胞培养中N-1 perfusion 培养场的种植方式细胞生长动态 细胞生长动态细胞特异性 perfusion 速率 (CSPR) 是指细胞特异性 perfusion 速率 (CSPR) 是指细胞特异性 perfusion 速率.一个中等的交易所.过程强化,过程强化.特定代谢速率是指特定的代谢速率.

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