药物治疗对运动诱导的支气管收缩和耐力运动员过敏炎症反应的影响
Ronaldo Aparecido da Silva1, Renata Nakata Teixeira2, Gerson Dos Santos Leite2
1Strictly Academic Postgraduate Program Institute of Medical Assistance for State Public Servants of São Paulo.
International journal of sports physical therapy
|August 4, 2025
概括
药物治疗有效地减少了耐力运动员的运动诱导支气管收缩 (EIB),改善了有氧健身. 这种改善发生在不改变过敏炎症反应 (AIR) 的情况下.
科学领域:
- 运动医学 运动医学
- 肺部病理学 肺部病理学
- 过敏和免疫学 过敏和免疫学
背景情况:
- 耐力运动员患有肺部疾病和过敏性炎症往往会经历性能下降.
- 运动诱导的支气管收缩 (EIB) 和过敏性炎症反应 (AIR) 等呼吸道疾病可能会对运动能力产生负面影响.
研究的目的:
- 研究药理治疗对减轻耐力运动员EIB和AIR的疗效.
- 为了确定医疗干预是否可以改善有呼吸道相关疾病的运动员的表现.
主要方法:
- 一个前性,受控的临床试验,涉及马拉松跑步者,使用eucapnic自愿高通风 (EVH) 对EIB进行查.
- 参与者被分为一个EIB+治疗组 (n=13) 和一个控制组 (n=18).
- 投资银行+组接受了吸入性皮质类固醇和长效支气管扩展剂,而两组都保持了训练习惯. 评估包括肺功能,运动测试,过敏症状和干预前后的炎症标志物.
主要成果:
- 与基线相比,药物治疗导致了EIB的显著减少,并使EIB+组的VO2峰值明显增加.
- 在治疗后的两组之间,没有观察到炎症媒介体表达的显著变化.
- 包括肺功能,过敏症状和炎症标志物在内的基线参数在EIB+和对照组之间没有显著差异.
结论:
- 药物治疗有效地减少了EIB,并提高了耐力运动员的有氧性能.
- 观察到的性能益处是独立于对过敏炎症反应的修改而实现的.
- 吸入性皮质类固醇和支气管扩展剂为经历了EIB的耐力运动员提供了可行的治疗策略.
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