阿托皮炎与中风风险之间的关联:系统性审查和元分析
Hong Pan1, Qing-Ping Han2, Min-Ling Zeng3
1Department of Internal Medicine, Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China.
Frontiers in neurology
|August 4, 2025
概括
这项研究发现,亚托皮性皮炎 (AD) 与中风风险增加之间存在显著联系. 这种关联在男性和缺血性中风中更为强烈,这表明阿尔茨海默病是一个独立的危险因素.
科学领域:
- 皮肤病学 皮肤病学
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 亚托皮炎 (AD) 是一种慢性炎症性皮肤疾病.
- 之前关于AD和中风风险之间的关联的研究已经产生了不一致的结果.
- 关于阿尔茨海默病和中风发生之间的相关性,目前还没有确定的共识.
研究的目的:
- 进行元分析和系统审查,以探索亚托皮性皮炎和中风风险之间的潜在关系.
- 综合观察性研究的证据,以澄清AD和中风之间的关联.
- 提供有关AD和中风发生情况的当前证据的全面概述.
主要方法:
- 在PubMed,Embase和Web of Science进行了系统的文献搜索,直到2025年1月.
- 包括12个观察性研究 (8个队列,2个病例控制,3个横截面) 与14,517,146名参与者.
- 进行了随机效应元分析,计算了危险比率 (HR) 和95%置信区间 (CI),并进行了灵敏度和子组分析.
主要成果:
- 在亚托皮性皮炎和中风风险增加之间发现了显著的相关性 (OR = 1.27,95% CI = 1.14-1.43).
- 亚组分析显示,男性 (OR = 1.31,95% CI = 1.07-1.60) 和缺血性中风 (OR = 1.14,95% CI = 1.00-1.30) 的相关性更强.
- 敏感性分析证实了研究结果的稳定性和可靠性.
结论:
- 亚托邦性皮肤炎独立地与中风风险增加有关.
- 这种联系在男性和缺血性中风亚型中尤为明显.
- 有证据表明,AD严重程度和中风风险之间存在正相关性.
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