慢性阻塞性肺部疾病的中国患者的治疗模式和三重疗法利用:对来自州数据库的现实数据的分析
Yan Chen1, Xinli Li2, Dongni Hou3
1Department of Pulmonary and Critical Care Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
概括
治疗COPD的三重疗法,包括吸入性皮质类固醇 (ICS),长效β2-激动剂 (LABA) 和长效肌抗体 (LAMA),在中国很常见. 大多数患者接受双重ICS+LABA治疗,但也使用三重治疗,通常是在其他治疗后进行的.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 药物治疗 药物治疗
- 现实世界的证据.
背景情况:
- 三重疗法 (吸入性皮质类固醇,长效β2-激动剂,长效肌酸抗剂) 已被公认为其在COPD管理中的好处.
- 有限的现实世界数据存在于中国COPD人群的三重疗法利用.
研究的目的:
- 研究中国慢性阻塞性肺病 (COPD) 的治疗模式.
- 通过使用现实世界的数据,评估中国COPD患者的三重治疗 (ICS+LABA+LAMA) 的利用和模式.
主要方法:
- 来自州数据库的COPD患者 (≥40岁) 的回顾性分析.
- 治疗方法分为单 (ICS或LAMA),双 (ICS+LABA) 和三 (ICS+LABA+LAMA) 的组合.
- 对治疗模式和序列的描述性分析.
主要成果:
- 在7888名患者中,有29.1%的患者接受了三重治疗 (ICS+LABA+LAMA) 平均3.27个月.
- 大多数患者 (68.6%) 接受了双重ICS+LABA治疗.
- 显著比例接受单次ICS (27.3%) 或LAMA (23.3%) 疗法,观察到常见的治疗过渡.
结论:
- 双 ICS + LABA 疗法是中国最常见的 COPD 治疗方法.
- 三重疗法也经常使用,许多患者从其他疗法过渡到三重疗法.
- 这项研究为中国的COPD治疗策略提供了有价值的见解.
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