血清总胆红素水平与腹腔大动脉化的关联:基于人口的横截面研究
Chunjiang Liu1, Kuan Li2, Guohua Wang1
1Department of General Surgery, Shaoxing People's Hospital (The First Affiliated Hospital, Shaoxing University), No. 568 Zhong Xing Road, Shaoxing, Zhejiang, China.
Mediators of inflammation
|August 4, 2025
概括
在美国人群中,血清总胆红素水平与腹腔大动脉化 (AAC) 和严重的AAC (SAAC) 呈现出U形的关联. 监测胆红素可能有助于预防AAC的发展.
科学领域:
- 心血管健康 心血管健康
- 代谢综合征是代谢综合征的一种.
- 生物化学 生物化学
背景情况:
- 腹腔大动脉化 (AAC) 是心血管疾病风险的标志物.
- 血清总胆红素是血新陈代谢的副产品,已经显示出抗氧化特性.
- 在一般人群中,血清总 bilirubin 和 AAC 之间的关系需要进一步研究.
研究的目的:
- 调查血清总胆红素水平与腹腔大动脉化 (AAC) 和严重的AAC (SAAC) 的患病率之间的关联.
- 通过使用大型,具有全国代表性的数据集,探索美国一般人口中的这种关联.
主要方法:
- 来自2013-2014年全国健康和营养检查调查 (NHANES) 的数据分析,涉及3016名参与者.
- 使用限制立方线 (RCS) 图表来可视化剂量反应关系.
- 采用加权多变量后勤回归和分层子组分析来调整混因素并检查特定人群.
主要成果:
- 在血清总胆红素水平和AAC和SAAC的患病率之间观察到一个显著的U形关联.
- 与最低四分位数相比,较高的胆红素水平 (Q3和Q4) 与AAC的几率增加有关.
- 在包括老年人 (年龄≥60岁),高血压,糖尿病 (DM) 和肥胖 (BMI≥30 kg/m2) 个体在内的子组中,U形模式尤其明显.
结论:
- 血清总胆红素水平与AAC和SAAC都有显著的U形关联.
- 这些发现表明,血清总 bilirubin 的低水平和高水平都可能与 AAC 的患病率增加有关.
- 优化血清总胆固醇水平可能在预防腹腔大动脉化方面发挥作用.
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