在类风湿性关节炎中认知障碍的评估
Olfa Saidane1, Khaoula Zouaoui2,3, Selma Bouden1
1Department of Rheumatology, Charles Nicolle Hospital, Tunis, Tunisia.
Mediterranean journal of rheumatology
|August 4, 2025
概括
近一半的风湿性关节炎 (RA) 患者经历认知障碍. 关键预测因素包括老年,低收入和疾病活动,突显了改善患者生活质量的早期干预的必要性.
科学领域:
- 类风湿病学 类风湿病学
- 神经心理学 神经心理学
- 公共卫生 公共卫生
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性炎症疾病,具有潜在的全身影响.
- 认知障碍越来越多地被认为是RA的并发症.
- 了解RA认知功能障碍的患病率和预测因素对于患者管理至关重要.
研究的目的:
- 为了确定类风湿性关节炎患者认知障碍的患病率.
- 确定与RA患者认知障碍相关的独立预测因素.
主要方法:
- 一项为期6个月的横截面病例控制研究,涉及35名RA患者和35名对照.
- 认知功能使用迷你精神状态检查 (MMSE),前部效率电池,5个字测试,时钟绘图测试和Trail Making Test part-A (TMT-A) 进行评估.
- 使用线性回归分析来确定认知障碍的预测因素.
主要成果:
- 通过MMSE评估的全球认知功能障碍在49%的RA患者中被发现.
- 认知障碍的患病率从34%到54%不等,取决于所使用的特定测试.
- 与对照组相比,RA患者在TMT-A上表现明显差 (p = 0.03).
- 认知障碍的预测因素包括晚年,农村环境,低收入,最近的RA过程,低疾病活性和低血糖.
结论:
- 认知障碍影响了大量 (49%) 风湿性关节炎患者.
- 早期识别相关因素对于改善RA患者的生活质量至关重要.
- 基于已识别的预测因子的有针对性的干预措施可以减轻RA的认知衰退.
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