基于家庭的结构化的生活方式修改干预计划的试验内成本效益分析,以减少心血管风险:PROLIFIC试验的结果
Ashis Samuel John1, Sanjay Ganapathi2, Sivadasanpillai Harikrishnan2
1Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
Global heart
|August 4, 2025
概括
这项研究表明,以家庭为基础的生活方式计划可以有效地减少心血管风险因素并改善生活质量. 该干预措施具有成本效益,为更广泛的采用提供了重要的公共卫生潜力.
科学领域:
- 预防心血管疾病预防心血管疾病
- 卫生经济学 卫生经济学
- 公共卫生干预措施 公共卫生干预措施
背景情况:
- 早发性冠状动脉心脏病对健康造成重大负担.
- 基于家庭的干预措施可以有效地改变生活方式.
- 成本效益分析对于评估公共卫生战略至关重要.
研究的目的:
- 评估针对性基于家庭的结构化的生活方式修改干预措施的成本效益,以减少心血管风险.
- 评估干预对风险因素和质量调整寿命年 (QALYs) 的影响.
主要方法:
- PROLIFIC研究是一项开放标签,集群随机对照试验.
- 干预包括查,结构化的生活方式改变和与护理联系,由非医生卫生工作者促进.
- 从卫生系统的角度分析了两年的成本,测量了风险因素的变化和使用EQ-5D-5L的QALY.
主要成果:
- 基于家庭的干预造成了每人157.5英的增量成本,在两年内获得了0.014个QALY.
- 在试验中的增量成本效益比率 (ICER) 为11,352 Int$/QALY.
- 系统血压,禁食血葡萄糖,HbA1c,总胆固醇和腰围的显著降低.
结论:
- 基于家庭的结构化的生活方式修改计划是降低心血管风险的成本效益.
- 该干预措施显示了生活质量的净收益,并有可能对公共卫生产生重大影响.
- 预计该计划在较长时间内大规模实施时,将更具成本效益.
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