在艾滋病毒/艾滋病的老年患者中,潜在不合适的药物和相关因素:一个多中心跨部门研究
Jia Li1, Dongsheng Hong2, Jiankun Dong1
1Department of Pharmacy of the First Affiliated Hospital, and Department of Social Medicine of School of Public Health, Zhejiang University School of Medicine, Hangzhou, 310058, People's Republic of China.
Clinical interventions in aging
|August 4, 2025
概括
潜在不合适的药物 (PIM) 使用影响超过23%的艾滋病毒/艾滋病的老年人,特别是那些有多种药物的老年人. 干预措施对于改善这种人群的药物安全至关重要.
科学领域:
- 老年病的医生 老年病的医生
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 携带艾滋病毒/艾滋病的老年人代表了一个具有复杂药物需求的弱势群体.
- 潜在不适当的药物 (PIM) 使用是老年人群的一个重大问题,可能导致不良健康结果.
- 了解这一特定群体中的PIM模式对于制定有针对性的安全策略至关重要.
研究的目的:
- 确定艾滋病毒/艾滋病老年患者潜在不适当药物 (PIM) 使用的患病率,模式和风险因素.
- 为了确定这个人群中最常用的特定类别的PIM.
- 为旨在提高艾滋病毒/艾滋病患者老年人药物安全性的干预措施的开发提供信息.
主要方法:
- 对2642名65岁及以上的艾滋病毒/艾滋病患者进行了药物使用的回顾性分析.
- 在2019年至2023年期间,从中国八个城市的21家医院收集了数据.
- 2023年美国老年病学学会的Beers标准被用于识别PIM,统计分析包括描述性统计,负二项式回归和多变量后勤回归.
主要成果:
- PIM使用的总体流行率为23.20%,禁用药物是最常见的类别 (51.87%).
- 虽然某些PIM类别的使用量下降了,但单个PIM的使用量呈现出增加的趋势.
- 多药 (OR=9.05) 和住院 (OR=1.38) 被确定为PIM在老年艾滋病毒/艾滋病患者中使用的显著预测因素.
结论:
- 艾滋病毒/艾滋病的老年患者中存在大量的PIM使用负担,需要改进药物管理.
- 有针对性的干预措施应专注于多药患者和需要住院治疗的患者.
- 特定于年龄的策略也可能有利于提高这种不断增长的人口中的药物安全性.
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