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Updated: Jun 15, 2026

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1

Published on: February 13, 2018

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巨细胞向保护神经结构和改善肌肉内在Charcot-Marie-Tooth 2J的小鼠模型中的肌肉内

Dennis Klein1, Neslim Ercan1, Xidi Yuan1

  • 1Department of Neurology, Developmental Neurobiology, University Hospital Würzburg, Würzburg, Germany.

Glia
|August 4, 2025
PubMed
概括

用PLX5622向巨细胞显著改善了轴突Charcot-Marie-Tooth (CMT) 疾病的小鼠模型中的外周神经病变. 这种治疗可以预防神经损伤并保持运动功能,突出显示巨细胞是CMT2J的治疗点.

关键词:
轴突退化的轴突退化轴心病症是一种轴心病症.殖民地刺激因子1遗传的外围神经病变巨细胞是一个巨细胞.神经炎症是一种神经炎症.

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Modeling Charcot-Marie-Tooth Disease In Vitro by Transfecting Mouse Primary Motoneurons07:43

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