肠肺轴在全身性硬化-间歇性肺病中的国际调查
Kristofer Andréasson1, Arissa Young2, Swapna Joshi2
1Lund University, Lund, Sweden.
Arthritis care & research
|August 4, 2025
概括
不同的肠道细菌与系统性硬化症相关的间歇性肺病 (SSc-ILD) 有关. 这项研究确定了与ILD存在和严重程度相关的特定细菌物种和通路,表明了新的治疗点.
科学领域:
- 微生物组研究的研究.
- 肺病理学 肺病理学
- 胃肠病学 胃肠病学
背景情况:
- 肠肺轴突出了肠道微生物群和肺部疾病之间的联系.
- 在全身性硬化症 (SSc) 中,肠道失调是常见的.
- 在全球范围内,肠道微生物群与SSc相关的间歇性肺病 (ILD) 之间的关系仍然未得到充分研究.
研究的目的:
- 描述SSc和ILD患者的肠道微生物群.
- 确定与SSc.中ILD存在和严重程度相关的特定细菌物种和功能途径.
- 在SSc病变发生过程中探索肠肺轴.
主要方法:
- 一个跨国SSc患者队列 (有和没有ILD) 提供了便样本.
- 步枪元基因组测序分析了物种层面上的微生物组成.
- 对CT扫描的定量图像分析 (QILD) 测量了ILD的程度;多变量分析确定了与ILD相关的微生物特征.
主要成果:
- 在285名参与者中,62.5%患有ILD.
- 患有ILD的患者表现出独特的肠道微生物特征,病原生物种增加.
- 特定的细菌物种和功能途径与SSc-ILD患者的放射性ILD程度 (QILD) 相相关.
结论:
- 独特的肠道细菌与SSc.中的ILD的存在和放射性程度有关.
- 这些发现表明,特定的肠道微生物或其代谢物可能有助于ILD的发病.
- 已识别的细菌物种代表了SSc-ILD.的潜在新型治疗点.
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