在接受静脉瘤手术的患者中,与听力损失相关的propofol敏感性增加:一项回顾性研究
Xuehua Zhou1, Yiru Wang, Songyuan Chi
1Department of Anesthesiology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Journal of neurosurgical anesthesiology
|August 4, 2025
概括
听力损失的患者在前庭神经瘤手术期间需要更少的propofol. 这一发现表明,手术前听力功能是影响神经外科手术麻醉需求的关键因素.
科学领域:
- 麻醉学 麻醉学
- 神经外科 神经外科
- 听力学 听力学是指听力学.
背景情况:
- 普罗波是神经外科手术中常用的麻醉剂,剂量通常取决于患者的体重.
- 影响醇需求的因素包括年龄,性别和认知功能.
- 术前听力功能的对普罗波需求的影响尚不清楚.
研究的目的:
- 为了研究手术前听力损伤和普罗波福尔敏感性之间的关系.
- 为了确定听力损失是否会影响在接受前庭神经瘤手术的患者的麻醉要求.
主要方法:
- 对475名接受前庭神经瘤切除术的患者进行了回顾性分析.
- 使用普罗波福和雷米芬坦尼尔进行全静脉麻醉 (TIVA),准BIS 40-60.
- 听力障碍定义为纯音调平均值 (PTA) ≥20dB;使用多变量线性回归.
主要成果:
- 听力受损的患者年龄较大,需要显著降低的普罗波福尔剂量 (中位数为96.7比109.0μg·kg-1·min-1).
- 在未调整和多变量分析中,听力损失 (PTA ≥20 dB) 与降低醇需求有关.
- 在调整了年龄,性别,ASA,BMI和麻醉提供者后,听力损失和降低的普罗波需求之间的关联仍然显著.
结论:
- 手术前的听力损失与在接受前庭神经瘤手术的患者中增加的普罗波福尔敏感性有关.
- 听力功能应被视为优化麻醉管理的普罗波福尔剂量的潜在因素.
- 这一发现强调了针对量身定制麻醉护理的全面患者评估的重要性.
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