与乌干达西南部不完全遵守基于多卢特格拉维尔的抗逆转录病毒疗法相关的因素
Cameron T Nutt1,2,3,4, Winnie R Muyindike5, Victoria Nanfuka5
1Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Journal of acquired immune deficiency syndromes (1999)
|August 4, 2025
概括
在乌干达,对tenofovir/lamivudine/dolutegravir (TLD) 的遵守率很高. 发作性头痛,而不是体重增加,与较低的坚持有关,而先前的抗逆转录病毒疗法 (ART) 经验改善了坚持.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 诺福维尔/拉米武丁/多卢特格拉维尔 (TLD) 是全球领先的抗逆转录病毒疗法 (ART).
- 多卢特格拉维尔是TLD的成分,与体重增加和神经精神病学影响有关.
- 这些不良事件对TLD遵守的影响需要进一步调查.
研究的目的:
- 评估乌干达西南部艾滋病毒成年人对TLD的坚持模式.
- 确定与不完全遵守TLD相关的因素.
- 检查杜洛特格拉维尔相关的不良影响与TLD遵守之间的关系.
主要方法:
- 一项前性队列研究的二次分析,涉及675名艾滋病毒成年人,持续48周.
- 参与者过渡到或启动了TLDART.
- 通过问卷评估依从性,非艾滋病毒药物使用和症状;审查了临床数据.
- 用通用估计方程逻辑回归模型来识别不完全遵守的预测因素.
主要成果:
- 在48周内,在642名参与者的8.4%中观察到不完全的TLD遵守.
- 发生性头痛与不完全依附相关 (aOR 1.68).
- 之前的ART经验 (aOR 0.38) 和使用≥1种非HIV药物 (aOR 0.48) 预测了更好的坚持.
- 感知体重增加与不完全遵守没有显著关联 (aOR 0.39).
结论:
- 在乌干达西南部,发作性头痛与不完全遵守TLD有关.
- 既定的药丸服用习惯,根据先前的ART经验和非HIV药物的使用,促进了更好的坚持.
- 与多卢特格拉维尔相关的体重增加似乎不会影响这个人群的TLD坚持.
相关概念视频
Factors Affecting the Risk of Infection
12.3K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.3K
Factors Affecting Protein-Drug Binding: Patient-Related Factors
114
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
114
Pulmonary Tuberculosis I
324
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
324
Factors Affecting Drug Distribution: Miscellaneous Factors
522
Drug distribution in the human body is a complex process influenced by various individual factors, including age, pregnancy, obesity, diet, body water composition, pH levels, and specific disease conditions.
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
Age plays a significant role due to differences in body composition among different age groups. Infants, for instance, have a higher proportion of total body water and lower albumin levels, a protein that binds drugs in the bloodstream. This unique composition in infants enhances the...
522
Factors Affecting Drug Response: Overview
2.4K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.4K
Factors Affecting Protein-Drug Binding: Drug-Related Factors
196
Drug binding to proteins is a complex phenomenon influenced by various drug-related factors, each playing a significant role in the interaction between drugs and proteins within the body.
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...
One crucial factor in drug-protein binding is the drug's lipophilicity or its affinity for fat. More lipophilic drugs tend to have higher binding extents. For example, highly lipophilic drugs like cloxacillin exhibit substantial protein binding, with as much as 95% of the drug binding to proteins. In...
196


