在阿尔茨海默病和前性痴呆症中神经发育的脆弱性
Perrine Laury Marie Siguier1,2, Mélanie Planton1,3,4, Bérengère Pages3
1ToNIC, Toulouse NeuroImaging Center, UMR 1214, Université de Toulouse, INSERM, Paul Sabatier University (UT3), Pavillon BAUDOT, TOULOUSE Cedex 3, France.
European journal of neurology
|August 4, 2025
概括
神经发育脆弱性 (DV) 与阿尔茨海默病 (AD) 和前性痴呆症 (FTD) 的早期发病有关. 这一漏洞没有影响对典型或非典型的AD/FTD变异的易感性.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 神经学 神经学
背景情况:
- 神经发育障碍 (NDD) 可能会影响阿尔茨海默病 (AD) 和前性痴呆症 (FTD) 的进展.
- 以前的研究集中在特定的NDD-AD/FTD配对上,忽视了对NDD和AD/FTD异质性的维度方法.
- 调查与AD/FTD临床表现和发病年龄相关的神经发育脆弱性 (DV) 是至关重要的.
研究的目的:
- 探索神经发育脆弱性 (DV) 与阿尔茨海默病 (AD) 和前性痴呆症 (FTD) 的临床表现之间的关联.
- 确定DV是否会影响AD/FTD患者发病年龄.
- 利用数据驱动的集群方法,对DV进行公正的分类.
主要方法:
- 预计招募84名AD/FTD参与者和41名匹配的对照.
- 将AD/FTD参与者分为典型 (记忆AD,行为FTD) 和非典型 (PPA,AD变体,FTD变体) 的呈现.
- 神经心理学评估和一个新的NDDs症状问卷,然后进行k-means聚类以确定DV+和DV-组.
主要成果:
- 在AD/FTD (18%) 和对照 (15%) 组之间,以及在典型 (21%) 和非典型 (11%) AD/FTD亚组之间,DV频率相似.
- 与DV-患者相比,DV+患者在8.0年内显著提前出现症状 (p=0.005).
- 在DV+患者中,发病时的中位数年龄为58岁.
结论:
- 神经发育的脆弱性 (DV) 可能使个体易患早期发病的阿尔茨海默病 (AD) 和前性痴呆症 (FTD).
- DV似乎不会影响对AD/FTD的典型与非典型变体的易感性.
- 对于精准医学和AD/FTD个性化治疗策略,需要对DV的神经生理基础进行进一步的研究.
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