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特里科巴尔特四色化物纳米颗粒通过重塑肠道微生物群和加强上皮质紧密结节来改善肠道屏障功能

Yin Chen¹, Na Zhao², Songling Han¹

¹State Key Laboratory of Trauma and Chemical Poisoning, Institute of Combined Injury of PLA, College of Preventive Medicine, Army Medical University, Chongqing, 400038, China. wangcheng@tmmu.edu.cn.

Biomaterials science

|August 4, 2025

概括

三聚四烯化物纳米颗粒 (Co3Se4 NPs) 通过促进有益细菌和短链脂肪酸 (SCFA) 来增强肠道屏障功能. 这种方法有效地治疗小鼠的炎症性肠病 (IBD) 和辐射诱导的肠损伤 (IRIII).

科学领域:

生物材料科学生物材料科学
胃肠病学胃肠病学
纳米技术纳米技术

背景情况:

肠道机械屏障的破坏与炎症性肠道疾病 (IBD) 和辐射诱导的肠道损伤 (IRIII) 有关.
目前针对这些疾病的医疗对策不足.
提高肠道微生物群和短链脂肪酸 (SCFA) 水平可以加强肠道屏障.

研究的目的:

调查三四烯化物纳米颗粒 (Co3Se4 NPs) 作为IBD和IRIII的治疗剂的潜力.
探索Co3Se4NP调节肠道微生物群和肠道屏障功能的机制.

主要方法:

使用生物矿物化方法合成了Co3Se4NP.
在小鼠中口服Co3Se4NP.
分析肠道微生物群的组成,SCFA的产生和肠道紧结蛋白的表达.
在德克斯硫酸盐和盐 (DSS) 诱导的大肠炎和马射线照射模型中评估治疗效果.

主要成果:

Co3Se4 NP的使用增加了肠道微生物的多样性,并丰富了SCFA产生细菌,特别是Alloprevotella.
升高的黄油酸 (BA) 水平激活了G蛋白结合受体43 (GPR43) 并诱导了肠细胞中的蛋白激酶B (AKT) 酸化.
观察到紧结蛋白 (occludin 和 zonula occludens-1) 的表达增加.
在小鼠中,Co3Se4 NPs改善了肠道失调和紧结的破坏,加强了机械屏障,并缓解了DSS诱导的大肠炎和IRIII.

结论:

Co3Se4 NP 是一种生物相容的纳米材料,能够重塑肠道微生物群.
这种纳米材料有效地强化了上皮紧接口,为IBD和IRIII提供了有前途的治疗策略.

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