在PTSD和神经精神疾病中神经S通路:一篇综述
Zhi-Cheng Zhu1, Xue-Jing Han2, Zhen He3
1Beijing Institute of Pharmacology and Toxicology, Beijing, China; Department of Pharmacology, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Biomolecules & biomedicine
|August 4, 2025
概括
神经S (NPS) 系统通过其受体 (NPSR) 作用,与创伤后应激障碍 (PTSD) 和其并发症有关. 遗传和临床前证据支持NPS-NPSR作为PTSD的治疗目标.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 创伤后应激障碍 (PTSD) 经常与焦虑,抑郁和物质使用障碍同时发生.
- 神经S (NPS) 系统,包括它的受体 (NPSR),是这些多样化的表型的潜在共同调节者.
- 遗传和神经化学发现表明NPS/NPSR参与核心PTSD特征和并发症.
研究的目的:
- 审查有关NPS/NPSR系统在PTSD及其常见并发症中的作用的研究.
- 评估针对PTSD和相关疾病的NPS-NPSR轴的治疗潜力.
主要方法:
- 从PubMed,Embase和Web of Science出版的2000年至2024年间发表的研究的叙事综述.
- 对遗传关联,临床前动物模型和神经生物学途径的分析.
主要成果:
- 功能性NPS受体 (NPSR) 基因多态性 (rs324981 A/T) 与增加PTSD风险和严重程度有关.
- 在动物模型中,NPS的使用减轻了焦虑,恐惧行为和戒断症状,同时改善了认知功能和疼痛感知.
- NPS影响关键的大脑电路和神经递质系统,包括多巴胺和催产素路径.
结论:
- NPS-NPSR轴是创伤后应激障碍及其并发症的有希望的治疗点.
- 临床转化中的挑战包括NPS降解和血脑屏障的透.
- 药物输送和NPSR配体开发方面的进展为未来的治疗策略提供了潜在的解决方案.
相关概念视频
Post-traumatic Stress Disorder
114
Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events,...
114
Role of Amygdala in Memory
399
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
One of the...
399
The Sympathetic Nervous System
96.7K
Overview
96.7K
Postsynaptic Potential (PSP)
3.4K
Postsynaptic potential (PSP) refers to a change in the electrical potential of a neuron when neurotransmitters released by presynaptic neurons bind to postsynaptic receptors. This potential can either be excitatory, leading to depolarization and ultimately action potential generation, or inhibitory, leading to hyperpolarization and suppression of the postsynaptic neuron.
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
There are two types of receptors: ionotropic and metabotropic.
The ionotropic receptor is the membrane protein that has an...
3.4K
Introduction to Biological Bases of Psychology
3.5K
Biopsychology serves as a vital bridge connecting the intricate domains of biology and psychology, shedding light on how biological systems influence psychological phenomena. This field scrutinizes the biological substrates of behavior and mental processes, emphasizing the nervous system along with the roles of neurotransmitters, hormones, and genetics. It also incorporates evolutionary perspectives to explain the adaptive nature of mental functions.
The nervous system, the cornerstone of...
The nervous system, the cornerstone of...
3.5K
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
961
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
961


