炎症性肠病患者患间歇性肺部疾病的风险增加
Bharati Kochar1,2,3, Jiangwei Sun4, Ola Olén5,6
1Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.
The American journal of gastroenterology
|August 4, 2025
概括
患有炎症性肠病 (IBD) 的人面临患间歇性肺部疾病 (ILD) 的风险更高. 这项全国性的研究证实了IBD和ILD之间存在显著的关联,影响了性结肠炎和克罗恩病患者.
科学领域:
- 胃肠病学和肺病学 胃肠病学和肺病学
- 流行病学 流行病学
- 慢性疾病研究 慢性疾病研究
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎和克罗恩病,越来越多地被认为是潜在的肠外表现.
- 建议IBD的肺部参与,但将IBD与间歇性肺部疾病 (ILD) 联系起来的强有力的流行病学数据仍然有限.
研究的目的:
- 调查炎症性肠病 (IBD) 与发展间歇性肺部疾病 (ILD) 的风险之间的联系.
- 为了检查这种风险在IBD的不同亚型,包括性结肠炎和克罗恩病.
主要方法:
- 在瑞典 (1969-2019) 进行的一项全国性队列研究确定了85,705名IBD患者和412,677名匹配的普通人群比较者.
- 考克斯回归分析用于计算ILD诊断的调整危险比率 (aHR),并与无IBD的兄弟姐妹进行二次比较.
主要成果:
- 与一般人群相比,IBD患者的ILD相对风险增加了48% (aHR为1.48,95%CI为1.30-1.69).
- 在性结肠炎和克罗恩病患者中观察到ILD风险增加.
- 与他们的兄弟姐妹相比,IBD患者的ILD风险明显更高 (aHR1.81,95%CI:1.43-2.27).
结论:
- 这项大规模的全国性研究表明,在被诊断患有炎症性肠病 (IBD) 的个人中,间歇性肺病 (ILD) 的风险明显且显著增加.
- 这些发现强调了在治疗IBD患者时考虑肺部并发症的重要性.
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