肺移植在患有高风险前列腺癌的男性
Jennifer Maling Slota1, Ridwan Alam1, Benjamin Louis Thomae2
1Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, USA.
Clinical transplantation
|August 4, 2025
概括
肺移植对于高风险前列腺癌 (PCa) 患者来说是可行的,如果在最终的癌症治疗之前优先考虑. 这种方法平衡了移植效益与癌症管理,扩大了接受者池.
科学领域:
- 在瘤学瘤学.
- 移植手术 移植手术
- 肺部病理学 肺部病理学
背景情况:
- 由于免疫抑制风险,活跃癌症患者的移植是有争议的.
- 前列腺癌 (PCa) 对暂时的非化疗管理具有有利的概况.
- 在确定癌症治疗之前,对高风险的PCa患者进行肺移植 (LT) 的评估至关重要.
研究的目的:
- 检查新诊断的高风险前列腺癌 (PCa) 患者肺移植 (LT) 的可行性和结果.
- 评估优先考虑LT而不是立即确定癌症治疗的安全性和有效性.
主要方法:
- 在2018年1月至2023年10月期间接受实体器官移植的患者的回顾性评估.
- 纳入标准:在最终的瘤治疗之前诊断高风险的PCa.
- 专注于末期器官功能障碍患者,需要加快LT.
主要成果:
- 两个患有末期肺病和高风险PCa的患者接受了加快的LT.
- 一名患者接受了移植前的雄激素剥夺疗法 (ADT) 和移植后的放射治疗.
- 两位患者在LT后24个月和10个月的时间内仍然活着,在经过管理的局部PCa下.
结论:
- 在经验丰富的中心中,优先考虑局部高风险PCa的LT是合理的.
- 通过PCa的特性,可以平衡移植效益与推迟癌症治疗.
- 应考虑扩大接收者池,以包括这些患者.
相关概念视频
01:28Kidney Transplant I: Introduction
60
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
60
01:26Kidney Transplant II: Surgical Procedure
76
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
76