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Updated: Sep 12, 2025

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
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评估dordaviprone的细胞染色体P450药物相互作用风险,使用生理学基础的药物动力学建模

Swati Jaiswal1, Nikunjkumar K Patel1, Hannah M Jones1

  • 1Certara Predictive Technologies, Simcyp Division, Certara Inc, Radnor, Pennsylvania, USA.

CPT: pharmacometrics & systems pharmacology
|August 4, 2025
PubMed
概括

开发了一种新的基于生理学的多达维的药动力学模型. 它预测药物相互作用,表明需要对CYP3A4抑制剂和诱导剂进行剂量调整,应避免使用.

关键词:
药物 药物相互作用瘤学 在瘤学方面.基于生理学的药理动力学.

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