美国成年人的久坐行为,高尿血和痛风之间的关联:全国代表性的横截面研究
Debin Chen1, Yining Li2, Yizhou Zhuang3
1Chronic and Endemic Disease Prevention and Control Division, Xiamen Center for Disease Control and Prevention, Xiamen, 361021, China.
Clinical rheumatology
|August 4, 2025
概括
久坐时间的增加 (每天超过8小时) 显著增加了美国成年人患高尿血和痛风的风险. 高尿路血症作为一个关键的调解者,特别是在男性和晚期慢性病患者中.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 代谢疾病 代谢疾病
背景情况:
- 久坐不动的行为,高尿血和痛风的患病率在全球范围内不断上升.
- 在美国成年人中,静坐时间和高尿血症/痛风风险之间的特定关系需要澄清.
研究的目的:
- 调查美国成年人中静坐时间和患上高尿血和痛风的风险之间的关联.
- 探索高尿血症在久坐时间与痛风关系中的调解作用.
主要方法:
- 分析了来自2007-2016年国家健康和营养检查调查 (NHANES) 的17634名美国成年人 (≥20岁) 的数据.
- 通过问卷评估静坐时间;血清尿酸和痛风的诊断分别通过实验室检测和医生评估得到证实.
- 使用加权后勤回归,限制立方线和调解分析来检查关联和调解效应.
主要成果:
- 较长的静坐时间 (>8小时/天) 与高尿素血 (OR 1.18) 和痛风 (OR 1.41) 的几率增加有关.
- 在久坐时间和高尿血和痛风风险之间观察到非线性关联.
- 超尿路血症占静坐时间和痛风之间的关联的15.93%;关联因性别和慢性病 (CKD) 阶段而有所改变.
结论:
- 长时间的久坐是美国成年人患高尿血和痛风的重要危险因素.
- 超尿血是连接久坐行为和痛风的途径中的关键调解者.
- 已识别的风险在男性和晚期CKD患者中更为明显,突出了特定人群的脆弱性.
相关概念视频
Genome-wide Association Studies-GWAS
14.2K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.2K
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
32
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
32
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
40
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
40
Urinary Tract Calculi I: Introduction
44
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
44
Urinary Tract Calculi III: Medical Management
23
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
23
Nephrotic Syndrome I : Introduction
28
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
28

![Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F61682.jpg&w=3840&q=50)
