在接受实体器官移植的艾滋病毒患者中药物相互作用
Bailey Thayer1, Caitlin A Trottier2, Onyema Ogbuagu2,3
1Department of Pharmacy, Yale New Haven Hosptial, New Haven, CT, USA.
Expert opinion on drug metabolism & toxicology
|August 4, 2025
概括
艾滋病毒感染者 (PWH) 现在可以接受移植,结果与一般人群相似. 谨慎管理抗逆转录病毒和抗拒药物对于防止相互作用和确保移植成功至关重要.
科学领域:
- 移植医学 移植医学
- 传染病 传染病 传染病
- 药理学 药理学是指药理学的学科.
背景情况:
- 艾滋病毒感染者 (PWH) 患有末期器官疾病的人现在有资格接受脏和肝脏移植.
- 使用来自艾滋病毒阳性捐赠者的器官移植的PWH移植结果与一般人群相似.
- 医疗和政治倡导已经取消了这些移植之前基于研究的限制.
研究的目的:
- 在移植后的PWH中审查抗逆转录病毒药物 (ARV) 和抗排斥药物之间的代谢途径和药物相互作用 (DDI).
- 突出DDI管理对ARV和抗拒药物的有效性和安全性的重要性.
- 强调治疗药物监测对抗排斥药物的作用.
主要方法:
- 发表论文和会议摘要的广泛文献评论.
- 包括从药物处方信息和监管提交的未公布数据.
- 来自PubMed,谷歌和谷歌学者 (1980-2024) 的数据.
主要成果:
- 确定了ARV和抗排斥药物之间的关键代谢途径和潜在的DDI.
- 强调了平衡ARV和抗拒药物治疗方案的关键需要.
- 强调治疗药物监测对于抗拒药物是必不可少的,因为治疗指数狭窄.
结论:
- 有效的DDI管理对于维护免疫抑制和抗病毒疗法的有效性和安全性至关重要 移植接受者与艾滋病毒.
- 需要仔细选择和剂量抗逆转录病毒和抗拒药物,以优化移植后的结果.
- 治疗药物监测有助于实现抗拒药物的目标药物水平,这对于PWH的移植成功至关重要.
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