延长贝塔乳输液对IV接入要求的影响
Kirstin J Kooda1, Julia Nelson2, Sara E Ausman3
1Department of Pharmacy, Mayo Clinic, Rochester, MN.
与传统剂量 (TD) 相比,延长输液 (EI) 贝塔乳治疗没有增加静脉注射 (IV) 接入需求. 这一发现表明,在临床上适用的情况下,实际挑战不应该阻碍EIβ-乳的使用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
背景情况:
- 贝塔乳酸抗生素对于治疗感染至关重要.
- 延长输液 (EI) 策略可以优化抗生素暴露.
- 有关增加静脉注射 (IV) 进入EI的要求存在担忧.
研究的目的:
- 为了比较beta-lactam治疗的延长输注 (EI) 和传统剂量 (TD) 之间的IV接入要求.
- 为了评估EIβ-乳的使用是否需要更多的IV接入与TD相比.
主要方法:
- 追溯分析了86名成年ICU患者,他们接受了抗伪药性β-乳糖药.
- 根据给药后治疗药物监测 (TDM),患者被分为TD和EI组.
- 匹配的1:1对TDM前后IV光量使用的比较.
主要成果:
- 在TDM之前,TD和EI组之间的IV光线使用中位数没有显著差异 (p=0.22).
- 在TDM后的组之间观察到类似的IV光线使用 (p=0.05).
- 延长输液β-乳治疗与增加IV接入需求无关.
结论:
- 延长输液β-lactam治疗似乎不会增加IV接入要求.
- 像IV接入这样的实际考虑不应该阻碍EIβ-乳糖的使用.
- 在没有增加IV接入负担的情况下,EIβ-乳糖可以在指示时安全地使用.
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