肺切除后与健康相关的生活质量的性别差异:系统性审查
Christina Beushausen1, Paula Duarte D'Ambrosio2, Rita Costa3
1Thoracic Surgery, Vivantes Klinikum Neukölln, Berlin, 12351, Germany.
概括
在肺癌的肺切除术后,女性可能面临与健康相关的生活质量 (HRQoL) 的更大挑战,经历更多的疼痛和心理健康问题. 需要进一步的研究来证实这些基于性别的差异.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 医疗保健服务研究 医疗服务研究
- 患者报告的结果
背景情况:
- 肺切除是肺癌的主要治疗方法.
- 与健康相关的生活质量 (HRQoL) 是癌症生存率以外的关键结果.
- 手术后HRQoL的潜在性别和性别差异需要调查,特别是随着早期肺癌治疗的发展.
研究的目的:
- 系统地审查和评估肺癌肺切除后HRQoL的性别相关差异.
- 确定基于性别的差异可能存在的特定HRQoL领域.
- 为非小细胞肺癌管理中以患者为中心的护理策略提供信息.
主要方法:
- 按照PRISMA指南进行的系统审查.
- 在Cochrane,MEDLINE,EMBASE和PubMed数据库中进行了搜索 (2014年1月 - 2024年6月).
- 包括报告性别分类HRQoL数据的肺切除后的研究;使用RoBINS-1评估偏差风险;质量综合数据.
主要成果:
- 在9861项选中,有11项研究符合纳入标准.
- 常见的HRQoL工具:VAS (30%),SF-36 (20%),SF-12 (20%),EORTC QLQ-C30 (20%).这些工具包括:
- 五项研究报告了基于性别的差异:女性经历了更多的手术后疼痛 (3/6),更差的睡眠质量 (2/2),以及更大的心理社会/身体问题 (3/6).
结论:
- 有限的证据表明,女性可能会经历肺切除后更大的不良HRQoL影响,特别是在疼痛,心理健康和身体恢复方面.
- 由于研究设计,仪器和数据收集时间点的异质性,研究结果应谨慎解释.
- 需要进一步的研究来阐明和解决肺癌手术中的性别特异性HRQoL结果.
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