纳FLD与心血管事件的关联:系统性审查和元分析
Mannat K Bhatia1, Archit Garg1, Junaid Ali1
1Department of Internal Medicine, Saint Peter's University Hospital/Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 增加了心血管疾病 (CVD) 的风险,即使没有晚期纤维化. 晚期纤维化增加了这种风险,特别是结合性心血管疾病事件.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 是对心血管疾病 (CVD) 风险的日益关注.
- 需要进一步澄清MAFLD和CVD结局之间的准确关系.
研究的目的:
- 系统地审查和对现有研究进行元分析.
- 量化MAFLD和心血管疾病事件之间的关联.
主要方法:
- 对相关研究进行了全面的数据库搜索.
- 使用元分析技术来综合包含的研究数据.
主要成果:
- 分析了49项涉及1,553,770人的研究.
- 没有晚期纤维化的MAFLD显示死亡,非死亡和结合心血管疾病事件的风险增加.
- 晚期纤维化的MAFLD与联合心血管疾病事件的风险更高有关.
结论:
- 无论纤维化阶段,MAFLD是心血管疾病的独立风险因素.
- 在MAFLD中晚期纤维化显著放大了结合心血管疾病事件的风险.
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