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Updated: Sep 12, 2025

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
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隐秘的内源转录启动产生有效的内源mRNA模板,用于C9orf72-关联的RAN翻译

Shannon L Miller1,2, Katelyn M Green1,2, Bradley Crone3

  • 1Department of Neurology, University of Michigan, Ann Arbor, MI 48109.

Proceedings of the National Academy of Sciences of the United States of America
|August 4, 2025
PubMed
概括

在C9orf72中,内部的重复扩张会导致ALS和FTD. 新的研究确定了神秘的,内源启动的C9orf72mRNAs是通过重复关联的非AUG转化产生有毒二重复蛋白质的主要来源.

关键词:
这就是ALS.神经退行症的神经退行症重复扩张疾病重复扩张疾病转录 转录 是一种转录.翻译翻译翻译翻译翻译翻译

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