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There have been five major extinction events throughout geological history, resulting in the elimination of biodiversity, followed by a rebound of species that adapted to the new conditions. In the current geological epoch, the Holocene, there is a sixth extinction event in progress. This mass extinction has been attributed to human activities and is thus provisionally called the Anthropocene. In 2019 the human population reached 7.7 billion people and is projected to comprise 10 billion by...
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Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
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概括
此摘要是机器生成的。

现代化正在减少人类微生物群的多样性,影响早期发育,免疫力和新陈代谢. 这种损失与新出现的疾病有关,需要进行干预以恢复微生物平衡.

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科学领域:

  • 人类生物学 人类生物学
  • 微生物组研究的研究.
  • 公共卫生 公共卫生

背景情况:

  • 对于健康和疾病至关重要的人类微生物组在最近几代人中经历了显著的多样性丧失.
  • 生命早期微生物群的获取影响着发育,特别是新陈代谢,免疫和认知.
  • 现代化对维持健康,多样化的微生物群构成挑战.

研究的目的:

  • 检查影响人类微生物群获取,维护和丧失的因素.
  • 探索改变的微生物组与最近疾病的出现之间的联系.
  • 为减轻与现代化相关的微生物组相关的健康问题提出解决方案.

主要方法:

  • 对影响微生物群的医学,公共卫生和饮食因素的审查.
  • 分析微生物组变化与当代疾病之间的关系.
  • 确定应对微生物群多样性丧失的策略.

主要成果:

  • 人类微生物群的多样性正在显著丧失.
  • 早期的微生物群落对于发育轨迹至关重要.
  • 现代生活方式因素与微生物组的破坏和疾病有关.

结论:

  • 由于现代化,人类微生物组的变化对健康构成风险.
  • 恢复微生物群多样性对于人类发展和疾病预防至关重要.
  • 需要针对医疗,饮食和公共卫生实践的干预措施.