看不见的灭绝是看不见的灭绝
Martin J Blaser1, Maria Gloria Dominguez-Bello2
11Center for Advanced Biotechnology and Medicine, Robert Wood Johnson Medical School and Rutgers School of Public Health, Rutgers University, New Brunswick, New Jersey, USA;
Annual review of microbiology
|August 4, 2025
概括
现代化正在减少人类微生物群的多样性,影响早期发育,免疫力和新陈代谢. 这种损失与新出现的疾病有关,需要进行干预以恢复微生物平衡.
科学领域:
- 人类生物学 人类生物学
- 微生物组研究的研究.
- 公共卫生 公共卫生
背景情况:
- 对于健康和疾病至关重要的人类微生物组在最近几代人中经历了显著的多样性丧失.
- 生命早期微生物群的获取影响着发育,特别是新陈代谢,免疫和认知.
- 现代化对维持健康,多样化的微生物群构成挑战.
研究的目的:
- 检查影响人类微生物群获取,维护和丧失的因素.
- 探索改变的微生物组与最近疾病的出现之间的联系.
- 为减轻与现代化相关的微生物组相关的健康问题提出解决方案.
主要方法:
- 对影响微生物群的医学,公共卫生和饮食因素的审查.
- 分析微生物组变化与当代疾病之间的关系.
- 确定应对微生物群多样性丧失的策略.
主要成果:
- 人类微生物群的多样性正在显著丧失.
- 早期的微生物群落对于发育轨迹至关重要.
- 现代生活方式因素与微生物组的破坏和疾病有关.
结论:
- 由于现代化,人类微生物组的变化对健康构成风险.
- 恢复微生物群多样性对于人类发展和疾病预防至关重要.
- 需要针对医疗,饮食和公共卫生实践的干预措施.
相关概念视频
Threats to Biodiversity
22.9K
There have been five major extinction events throughout geological history, resulting in the elimination of biodiversity, followed by a rebound of species that adapted to the new conditions. In the current geological epoch, the Holocene, there is a sixth extinction event in progress. This mass extinction has been attributed to human activities and is thus provisionally called the Anthropocene. In 2019 the human population reached 7.7 billion people and is projected to comprise 10 billion by...
22.9K
Conservation of Declining Populations
9.7K
Conservation of declining population focuses on ways of detecting, diagnosing, and halting a population decline. The approach uses methods to prevent populations from going extinct.
9.7K
Conservation of Small Populations
13.6K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
13.6K
The Fossil Record
25.6K
The fossil record documents only a small fraction of all organisms that have ever inhabited Earth. Fossilization is a rare process, and most organisms never become fossils. Moreover, the fossil record only exhibits fossils that have been discovered. Nevertheless, sedimentary rock fossils of long-lived, abundant, hard-bodied organisms dominate the fossil record. These fossils offer valuable information, such as an organism's physical form, behavior, and age. Studying the fossil record helps...
25.6K
Limits to Natural Selection
32.3K
Organisms that are well-adapted to their environment are more likely to survive and reproduce. However, natural selection does not lead to perfectly adapted organisms. Several factors constrain natural selection.
32.3K
Habitat Fragmentation
17.9K
Habitat fragmentation describes the division of a more extensive, continuous habitat into smaller, discontinuous areas. Human activities such as land conversion, as well as slower geological processes leading to changes in the physical environment, are the two leading causes of habitat fragmentation. The fragmentation process typically follows the same steps: perforation, dissection, fragmentation, shrinkage, and attrition.
17.9K


