对循环硫化物采用一种无催化剂的方法,通过并联核替代和分子内硫化
Wenjing Wang1, Shanyue Li1, Wei Zhou1
1State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, College of Pharmacy, Jinan University, Guangzhou 510632, China.
Organic letters
|August 4, 2025
概括
这项研究引入了一种新的无催化剂并联反应,用于合成循环硫化物. 这种高效的方法使用易于获得的硫酸盐,避免复杂的硫酸盐制备.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
- 药用化学 医学化学
背景情况:
- 传统的硫化方法通常需要大量的硫酸试剂的预制.
- 在有机合成中,开发有效和精简的循环硫化物合成路径至关重要.
研究的目的:
- 开发一种新的,无催化剂的双重反应,用于合成循环硫化物.
- 建立一种高效的方法,使用易于获得的原材料构建中型和宏环型硫乙烯.
主要方法:
- 采用了一种涉及核替代和分子内硫化反应的双重反应.
- 基结合的亚与硫酸盐发生反应.
- 反应在现场进行,产生没有预功能化的硫酸盐前体.
主要成果:
- 没有催化剂的双重反应有效地产生了中等到良好的循环硫化物.
- 该方法成功合成了各种中等大小和宏环型硫乙烯,包括8,9,10,13,15和26个环.
- 反应系统温和,避免需要预先合成的硫酸硫酸盐.
结论:
- 这种新的双重方法为循环硫化物和硫乙烯提供了一个高效和方便的途径.
- 硫酸盐前体的现场生成简化了合成过程,使其非常实用.
- 开发的方法适用于构建多种循环乙烯结构,包括具有挑战性的宏观循环.
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