在国家癌症研究所的先研究中选择多种癌症检测试验的框架
Elyse LeeVan1, Amanda L Skarlupka2, Christos Patriotis1
1National Cancer Institute, Rockville, MD, United States.
概括
国家癌症研究所 (NCI) 制定了一个框架,用于评估未来癌症查试验的多种癌症检测 (MCD) 测试. 这一过程为先研究确定了有前途的MCD测定,优先考虑临床研究的技术.
科学领域:
- 在瘤学瘤学.
- 生物技术是生物技术.
- 临床试验 临床试验
背景情况:
- 国家癌症研究所 (NCI) 成立了癌症查研究网络 (CSRN),以推进癌症检测研究.
- 首个CSRN研究,先研究,旨在评估随机对照试验中多种癌症检测 (MCD) 测试的可行性.
研究的目的:
- 概述NCI的框架,以吸引MCD测试开发人员.
- 描述使用生物银行参考集评估新兴MCD技术的方法.
- 详细说明"先研究"中适合目的的MCD试验的选择过程.
主要方法:
- 参与了MCD测试开发人员,并使用AI和机器学习评估了23个不同的测试.
- 在使用来自三个生物库的标本的九个试验中进行了盲目的性能评估.
- 为开发人员提供独立的性能评估,以改进测试.
主要成果:
- 在评估过程结束后,两家测试公司被选中参加先研究.
- 测试开发人员利用独立评估来提高MCD测试的性能.
- 该框架促进了MCD测试性能的透明和公平评估.
结论:
- 美国国家医学研究所建立了一个强有力的过程,用于为临床研究和公共卫生选择有前途的MCD试验.
- 其他机构和网络可以采用这种测试选择框架来优先考虑癌症查技术.
- 高性能技术的有效选择对于资源密集型的大规模癌症查试验至关重要.
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