相关实验视频
Updated: Sep 12, 2025

09:15
In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
784
在CVVH与RCA期间比较两种不同的二碳酸盐替代液体的协议:前性,随机化,受控试验
Blood purification
|August 4, 2025
概括
本研究将高二碳酸盐液 (HBF) 和低二碳酸盐液 (LBF) 进行比较,对重症患者进行连续静脉静脉血过,并进行区域酸盐抗凝治疗. 假设LBF可以减少酸干扰,改善患者的治疗结果.
科学领域:
- 临界护理脏病学重症监护
- 脏替代疗法是指脏替代疗法.
- 酸平衡是指酸平衡的情况.
背景情况:
- 在连续静脉静脉血过 (CVVH) 期间,特别是在区域酸盐抗凝剂 (RCA) 时,酸干扰很常见.
- 最近的证据表明,低二碳酸盐 (HCO3-) 替代液可以在连续脏替代疗法 (CRRT) 期间改善酸控制.
研究的目的:
- 在重症患者接受高二碳酸盐液 (HBF) 与低二碳酸盐液 (LBF) 在CVVH与RCA期间进行酸平衡比较.
- 为了测试LBF导致pH和HCO3-外流率明显降低的假设,与HBF相比.
主要方法:
- 一项前性,随机的,受控的,开放的,交叉的试点研究,涉及需要RRT的重症患者.
- 两种替代液体 (Phoxilium和Biphozyl) 在1:1区块随机化中与48小时后交叉进行比较.
- 主要终点:每一个治疗阶段在16-48小时内出现pH>7.45或HCO3->26 mmol/l外流,使用通用估计方程 (GEE) 分析.
主要成果:
- 目前正在招募研究人员,计划招募88名参与者.
- 数据分析和出版预计将在2025年试验完成后完成.
结论:
- 预计BiPhox-Trial的结果将广泛适用于需要CVVH与RCA的重症监护患者.
- 这项研究旨在指导临床实践,通过确定LBF在RCA的CVVH期间是否提供比HBF更稳定的酸参数.
相关概念视频
Continuous Renal Replacement Therapy
144
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
144
Titration of Polyprotic Base with a Strong Acid
875
The titration of a polyprotic base such as sodium carbonate with a strong acid such as hydrochloric acid results in two equivalence points on the titration curve. At the first equivalence point, the carbonate ions in the base are completely converted to bicarbonate ions. The second equivalence point corresponds to the complete conversion of bicarbonate ions to carbonic acid, which dissociates into carbon dioxide and water. The region before the first equivalence point corresponds to the...
875
Hemodialysis II: Procedure and Complications
133
DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
133
Anticoagulant Drugs: Low-Molecular-Weight Heparins
909
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
909
Blood Studies I: ABG and VBG
736
Blood studies are critical in the medical field, enabling healthcare professionals to assess a patient's health status accurately. This page will focus on two significant blood studies: Arterial Blood Gas (ABG) and Venous Blood Gas (VBG).
Arterial Blood Gas (ABG)
Arterial Blood Gas (ABG) studies are crucial for assessing the lungs' ability to supply oxygen and remove carbon dioxide, reflecting the patient's ventilation status. They also help understand the kidneys' capacity to...
Arterial Blood Gas (ABG)
Arterial Blood Gas (ABG) studies are crucial for assessing the lungs' ability to supply oxygen and remove carbon dioxide, reflecting the patient's ventilation status. They also help understand the kidneys' capacity to...
736
Bicarbonate-Carbonic Acid Buffer
3.0K
The carbonic acid-bicarbonate buffer system is critical for maintaining the body's pH balance. It operates on the equilibrium:
3.0K

