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结构上多样化的多基基与除草剂活性从真菌Aspergillus aculeatusatus

Fei Liu¹, Shanshan Hong¹, Xiaoxia Gu¹

¹Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

|August 4, 2025

概括

这项研究分离了15种新的多基基,A-O,从阿斯伯吉卢斯aculeatus. Aculeatides J和K表现出显著的除草剂活性,为新的除草剂提供了潜力.

科学领域:

自然产品化学自然产品化学
菌类学菌类学是指菌类学.
化学生态化学生态学

背景情况:

像Aspergillus aculeatus这样的内菌是结构多样化的二次代谢物的丰富来源.
聚基化物 (Polyketides) 是一大类具有广泛生物活性的自然产品.
研究真菌内细胞可以导致发现新的生物活性化合物.

研究的目的:

从内生菌Aspergillus aculeatus中分离和描述未描述的多基基.
用先进的光谱技术阐明新化合物的化学结构.
评估分离化合物的生物活性,特别是它们的除草剂潜力.

主要方法:

使用色谱技术分离化合物.
通过全面的光谱数据分析 (NMR,MS) 阐明结构.
使用电子循环二元论 (ECD) 计算和比较,Mo2(OAc) 4诱导的ECD,Rh2(OCOCF3) 4诱导的ECD和修改的莫舍尔法来确定绝对配置.

主要成果:

他们分离出了15种新的多基基,命名为aculeatides A-O,以及一种已知的化合物,xylarinol A.
甲基甲基和乙基甲基是新的[c]素衍生物,具有C6侧链.
Aculeatides C-I 具有带有独特 C8 侧链的福环系统.
秋叶类J和K表现出显著的除草剂活性,其IC50值分别为3.01 ± 0.40 μM和3.33 ± 0.52 μM.

结论:

固体真菌Aspergillus aculeatus产生各种各样的多基类,包括新的结构类.
乙烯酸J和乙烯酸K表现出有前途的除草剂活性,需要对农业应用进行进一步研究.
结构多样性和生物活性突出显示了真菌内植物作为新天然产品来源的潜力.

关键词:

亚斯伯吉拉斯 (Aspergillus aculeatus) 是一种植物.子[c]氧胺是一种福兰是一种酸.具有除草剂活性.这种植物属于Trichocomaceae.

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