脂质积累产品与中风发病率之间的关联:基于CHARLS的全国队列研究
Zhixian Zhu1, Xiaofan Miao2, Heng Wang1
1Department of Laboratory Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210029, China.
概括
脂质积累产品 (LAP) 与中国老年人中风风险增加有关. 当LAP超过28.140时,中风发生率显著上升,突出了LAP.
科学领域:
- 心血管流行病学心血管流行病学
- 代谢综合征标志物 代谢综合征标志物
- 中风风险因素 中风风险因素
背景情况:
- 脂质积累产物 (LAP) 与心血管疾病有关.
- 关于中国中年和老年人中LAP和中风风险的有限的大型队列研究存在.
研究的目的:
- 研究45岁及以上的中国成年人中LAP与中风风险之间的关联.
主要方法:
- 利用了来自中国健康与退休长度研究 (CHARLS) 的数据.
- 包括6,726名没有先前中风史的参与者.
- 采用Cox比例危险回归和受限立方斜线分析,用于关联和剂量反应评估.
主要成果:
- 对于每一个标准偏差增加的LAP,就观察到27.9%的中风风险增加.
- 发现了一个非线性关联,转折点在LAP = 28.140.
- LAP与中风风险之间的正相关性在各个子组中一致,并且独立于其他风险因素.
结论:
- 在研究的人群中,LAP与中风风险有积极的非线性关系.
- 升高的LAP水平 (28.140以上) 与中风发病率的增加有关.
- LAP可以作为一种有价值的工具来识别高风险中风的个体.
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