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功能障碍与抑郁和焦虑症状严重程度之间的遗传重叠:来自GLAD研究的证据
Megan Skelton1,2, Jessica Mundy1,2, Abigail R Ter Kuile1,2
1Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Psychological medicine
|August 4, 2025
概括
抑郁和焦虑症状的遗传责任在很大程度上与功能障碍重叠. 这表明,功能障碍措施无法捕捉这些疾病中超出症状严重程度的显著额外遗传风险.
科学领域:
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
- 心理健康研究 心理健康研究
背景情况:
- 功能障碍是主要抑郁症和焦虑症的诊断标准,但经常被忽视.
- 症状严重程度和功能障碍是这些疾病的不同但相关的方面.
- 了解功能障碍的遗传基础对于全面了解这些疾病至关重要.
研究的目的:
- 为了确定功能障碍是否反映了除了抑郁和焦虑症状之外的独特遗传责任.
- 为了估计抑郁症状,焦虑症状和功能障碍的遗传性.
- 分析这些关键指标之间的遗传相关性.
主要方法:
- 分析了17130名来自遗传链接到焦虑和抑郁症 (GLAD) 研究的个人.
- 使用的患者健康问卷-9 (抑郁症),通用焦虑障碍-7 (焦虑症) 和工作和社会适应量表 (功能障碍) 分数.
- 使用全基因组关联研究 (GWAS) 与REGENIE,GCTA-GREML用于遗传性,以及两种-GREML用于遗传相关性.
主要成果:
- 在所有三个措施中都观察到适度的表型相关性 (r=0.50-0.69).
- 在所有尺度中发现了基于单核酸多态的显著,低的遗传性 (h2SNP=0.11-0.19).
- 高基因相关性 (rg=0.79-0.87) 表明遗传影响在很大程度上重叠.
结论:
- 症状严重程度的遗传变异与影响抑郁症和焦虑症功能障碍的遗传变异在很大程度上重叠.
- 功能障碍,虽然在临床上是相关的,但似乎不代表超出症状措施的大量额外的遗传责任.
- 研究结果表明,在这些常见的精神健康状况中,症状表现和功能后果之间存在共同的遗传基础.
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