对抗超级细菌的细菌菌体的实验到大规模生产的最新情况:一项审查
Mohammadreza Rahimian1, Elham Mohammadi2, Mohammad Aghazadeh-Soltan-Ahmadi1,3
1Department of Medical Biotechnology, Faculty of Medicine, Istanbul Aydin University, Istanbul, Turkey.
Critical reviews in biotechnology
|August 4, 2025
概括
菌体 (菌体) 为治疗感染和提高食品安全提供了抗生素的有希望的替代品. 这篇评论探讨了菌体的生产,人工智能集成和大规模应用来打击抗生素耐药性.
科学领域:
- 微生物学和生物技术
- 传染病研究 传染病研究
- 农业科学 农业科学
背景情况:
- 抗生素耐药性是一个日益严重的全球健康危机,需要替代治疗策略.
- 菌体 (菌体) 是感染细菌的病毒,正在重新评估作为抗生素耐药性的解决方案.
- 菌体研究对于医学,食品安全和可持续农业的应用至关重要.
研究的目的:
- 审查当前和新兴的菌体 (菌体) 生产和应用的技术.
- 突出高通量测序,生物信息学和人工智能 (AI) 在促进菌体研究中的作用.
- 为工业,农业和医疗领域提供基于菌体的解决方案的全面概述.
主要方法:
- 审查关于菌体研究,生产技术和人工智能应用的现有文献.
- 分析高通量测序和生物信息学工具用于菌体识别和表征.
- 探索用于大规模菌体生产和封装的上游和下游加工.
主要成果:
- 关键的菌体检测方法 (宿主范围,爆发大小,稳定性) 的标准化对于生产至关重要.
- 先进的测序和生物信息工具使全面的菌体识别和分析成为可能.
- 人工智能 (AI) 增强了菌体研究的准确性,耐药性分析和宿主预测.
结论:
- 菌体生产方法,包括上游和下游加工,需要优化用于工业和农业用途.
- 封装菌体生产和人工智能驱动的自动化系统代表了定制菌体应用的未来方向.
- 本综述为研究人员和行业专业人士提供了基础知识,以推进针对抗生素耐药性的菌体战略.
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