在mRNA疫苗接种后,TNF抑制剂会影响诱导和维持尖端特异性的B细胞反应
Laura Yl Kummer1,2, Lisan H Kuijper1, Laura Fernández Blanco1,2
1Sanquin Research, Amsterdam, the Netherlands.
RMD open
|August 4, 2025
概括
瘤坏死因子抑制剂 (TNFi) 在SARS-CoV-2疫苗接种后损害了生殖中心衍生的B细胞的发展,导致抗体反应减少. 这会影响炎症性疾病患者的长期免疫力.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 类风湿病学 类风湿病学
背景情况:
- 瘤坏死因子抑制剂 (TNFi) 对于治疗免疫媒介炎症性疾病 (IMID) 至关重要.
- TNFi疗法可以减少疫苗抗体反应,但机制尚不清楚.
- 了解TNFi对幽默免疫的影响对于优化疫苗接种策略至关重要.
研究的目的:
- 调查TNFi如何影响SARS-CoV-2 mRNA疫苗接种后的B细胞和CD4+T细胞反应.
- 阐明TNFi对生殖中心 (GC) 衍生的B细胞分化和维护的影响.
主要方法:
- 在15名TNFi治疗的炎症性肠病 (IBD) 患者,9名非免疫抑制IBD患者和10名健康对照患者中比较了SARS-CoV-2尖端特异性的B细胞和CD4+T细胞反应.
- 利用光谱流细胞计用于B细胞表征和激活诱导的CD4+T细胞标记检测.
- 分析了T毛囊辅助细胞和GC衍生的B细胞群 (CD11c-CD71+).
主要成果:
- TNFi没有影响尖端特异性的CD4+T细胞频率或表型,包括T毛囊辅助细胞.
- 接受TNFi治疗的患者在接种疫苗后3-6个月显示总尖峰特异性B细胞频率降低,IgG+记忆性B细胞频率降低.
- 在接种疫苗后的早期,TNFi疗法降低了GC衍生的B细胞 (CD11c-CD71+) 的诱导,而额外毛囊B细胞反应 (CD11c+) 没有受到影响.
结论:
- 在SARS-CoV-2疫苗接种后,TNFi治疗会损害生殖中心衍生的B细胞的分化.
- 这种GC B细胞发育的干扰可能解释了在TNFi治疗患者中观察到的抗体反应的减少.
- 这些发现突出了TNFi影响幽默免疫力的特定机制,为未来的疫苗开发和患者管理提供了信息.
更多相关视频
06:15Characterization of Thymus-dependent and Thymus-independent Immunoglobulin Isotype Responses in Mice Using Enzyme-linked Immunosorbent Assay
Published on: September 7, 2018
9.5K
06:03Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
Published on: September 20, 2024
1.4K
相关概念视频
B Cell Activation and Differentiation
5.7K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
5.7K
Vaccinations
45.3K
Overview
45.3K
Immune Response Against Viral Pathogens
917
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
917
T Cell Activation and Clonal Selection
4.7K
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
4.7K
T Cell Types and Functions
1.4K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.4K
