Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Cancer Therapies02:49

Cancer Therapies

7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

660
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
660
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

5.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
Cancer Vaccines01:30

Cancer Vaccines

510
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
510

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

16S ribosomal RNA modification drives transcript-specific translation efficiency.

bioRxiv : the preprint server for biology·2026
Same author

A dietary switch promotes sensory neuron-dependent cancer-associated cachexia.

Science (New York, N.Y.)·2026
Same author

Cancer chemo-immunotherapy: time will tell.

Cancer immunology research·2026
Same author

Anatomical dynamics define cancer cachexia subtypes and identify systemic inflammation as a marker of lethal wasting.

medRxiv : the preprint server for health sciences·2026
Same author

Cancer cachexia: A tumor-driven disorder of whole-body homeostasis.

Cancer cell·2026
Same author

Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity.

Nature·2026
Same journal

ATR senses stiff extracellular matrix to promote epithelial-to-mesenchymal transition and immune suppression.

The Journal of clinical investigation·2026
Same journal

A peripheral subpopulation of retinal pigment epithelium resists oxidative damage through SERPINE3-mediated Caspase-1 inhibition.

The Journal of clinical investigation·2026
Same journal

PTEN deficiency confers sensitivity to ATR inhibitor-based treatment in high-grade serous ovarian cancer.

The Journal of clinical investigation·2026
Same journal

CD20+ T follicular helper-like cells drive antigen-specific autoimmunity in bullous pemphigoid.

The Journal of clinical investigation·2026
Same journal

Fate-mapping infiltrating monocytes following experimental myocardial infarction revealsdifferentiation trajectories in the infarcted heart.

The Journal of clinical investigation·2026
Same journal

Pharmacokinetics and pharmacodynamics of a long-acting monoclonal antibody against malaria in African adults.

The Journal of clinical investigation·2026
查看所有相关文章

相关实验视频

Updated: Sep 12, 2025

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

16.5K

癌症治疗和缓解症治疗

Tuba Mansoor Thakir1,2, Alice R Wang1,3,4, Amanda R Decker-Farrell1

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

The Journal of clinical investigation
|August 4, 2025
PubMed
概括
此摘要是机器生成的。

癌症疗法可以通过影响肌肉和大脑等器官,使消耗综合征 (cachexia) 恶化. 将生理措施与瘤反应相结合,对于有效的癌症治疗和患者福祉至关重要.

更多相关视频

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

19.1K
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

9.0K

相关实验视频

Last Updated: Sep 12, 2025

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
08:55

The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia

Published on: November 30, 2016

16.5K
The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

19.1K
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
06:38

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis

Published on: September 12, 2019

9.0K

科学领域:

  • 在瘤学瘤学.
  • 代谢过程中的代谢.
  • 生理学 生理学 生理学

背景情况:

  • 癌症治疗的目的是消除瘤,但可能导致显著的副作用.
  • 癌症相关的缓冲症是一种复杂的综合征,涉及体重减轻,炎症和代谢变化.
  • 新出现的证据表明,癌症治疗可以直接导致或恶化.

研究的目的:

  • 为了研究癌症治疗干预措施和缓解症的病理生理学的交叉点.
  • 探讨治疗如何影响涉及到缓冲症的关键器官系统.
  • 突出综合临床试验终点的需要.

主要方法:

  • 关于癌症疗法和缓解症机制的文献综述.
  • 专注于化疗和向治疗的效果.
  • 检查受影响器官中的分子通路 (例如IL-6,GDF-15,NF-κB,PKA/CREB).

主要成果:

  • 癌症疗法可以调高IL-6和GDF-15等因素,导致食欲下降和负能量平衡.
  • 治疗可以激活肌肉和脂肪组织中的信号通路 (NF-κB,PKA/CREB),从而导致缩.
  • 治疗干预与癌症进展共享生物途径,在驱动卡赫克西亚方面具有共同的作用.

结论:

  • 癌症治疗可以通过对器官系统的直接影响加剧缓解症.
  • 了解治疗时间和方法是管理缓冲症的关键.
  • 临床试验应包括生理终点,以评估患者的整体幸福感和治疗影响.