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Updated: Sep 12, 2025

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在类风湿性关节炎中探索IL-21/IL-21R信号通路:对同胞细胞存活和疾病进展的影响

Qiuhua Chen1, Shuntao Lin2, Sijie Wang3

  • 1The First Clinical Medical College of Jinan University, Guangzhou, GuangDong, China.

Immunological investigations
|August 4, 2025
PubMed
概括

干白素-21 (IL-21) 和它的受体 (IL-21R) 通过USP18.通过平衡自和内质网膜应激 (ERS) 来促进类风湿性关节炎纤维细胞样同胞细胞 (RA-FLS) 存活率. 这一途径影响了类风湿性关节炎的关节损伤.

关键词:
细胞内膜网膜应激压力通过IL-21/IL-21R路径.在USP18/GSDMD轴上纤维细胞类同胞细胞类似于纤维细胞.类风湿性关节炎 类风湿性关节炎

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