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乳酸信号导致免疫-炎症热点的聚合,SLC5A12阻断促进了它们的分辨率

Michelangelo Certo¹, Elena Pontarini², Sebastian G Gilbert^3,4

¹Department of Inflammation and Ageing, School of Infection, Inflammation and Immunology, College of Medicine and Health, University of Birmingham, Birmingham, UK. m.certo@bham.ac.uk.

Nature metabolism

|August 4, 2025

概括

在Sjögren的宫外淋巴状结构 (ELS) 组织.

科学领域:

免疫学免疫学免疫学
代谢途径代谢途径
自身免疫性疾病是一种自身免疫性疾病.

背景情况:

异位淋巴体结构 (ELS) 是炎症组织中的细胞聚合物,与自身免疫性疾病,癌症和感染有关.
ELS驱动B细胞成熟,并且越来越多地被认为是它们在疾病发病过程中的作用.
了解ELS的发展对于疾病的阐明和治疗策略至关重要.

研究的目的:

调查代谢途径和代谢物在ELS组织中的作用.
确定在Sjögren病 (SjD) 中ELS的关键调节者.
探索针对自身免疫性疾病中的代谢途径的治疗潜力.

主要方法:

对Sjögren病中的代谢途径和特定代谢物的分析.
研究了乳酸和乳酸载体在ELS组织中的作用.
通过SLC5A12阻断来抑制乳酸摄取的效果进行了评估.

主要成果:

乳酸和代谢途径被确定为SjD中ELS组织的主调节者.
通过阻断乳酸运输体 (SLC5A12) 来抑制乳酸吸收,证明了显著的效果.
阻断SLC5A12导致炎症性细胞因子减少,增强T细胞退出,并减少ELS内的T细胞和B细胞区域.

结论:

代谢途径,特别是乳酸,对于Sjögren病中的ELS组织至关重要.
针对像SLC5A12这样的乳酸转运体,为自身免疫性炎症疾病提供了一个新的治疗检查点.
抑制乳酸摄取促进多维的促解效应,影响炎症组织内的免疫细胞动态.

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